Blood From COVID-19 Survivors Saving Lives – In the past two weeks, blood centers across the U.S. have accelerated efforts to collect COVID-19 convalescent plasma on the theory it contains protective antibodies that can transfer immunity from a patient who had the disease to someone still suffering.
The experimental practice was used during the devastating 1918 flu, as well as to treat measles in the 1930s. More recently, plasma therapy has been used to treat victims of Ebola, SARS and H1N1 influenza. This year, an early review of five critically ill COVID-19 patients in China found that they appeared to improve after receiving convalescent plasma.
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But the treatment is only now being studied in multiple clinical trials. FDA officials made clear that while the agency authorized the treatment for emergency use in serious or critically ill COVID-19 patients, much remains unknown. “Although promising, convalescent plasma has not yet been shown to be safe and effective as a treatment for COVID-19,” the agency wrote.
It remains uncertain, for instance, at what point in illness the therapy could be most helpful. Early research suggests that convalescent plasma may be most effective when given to people before they get sick or early in the course of the disease, said Arthur Caplan, director of the division of medical ethics at New York University School of Medicine.
But that doesn’t deter families desperate for a solution, he acknowledged. “I understand that you might want us to try anything and everything,” he said.
Fewer than 100 people so far have been treated with plasma through the emergency avenues approved by the FDA, according to the AABB, an international nonprofit focused on transfusion medicine and cellular therapies. The group has partnered with SurvivorCorps, a grassroots movement aimed at encouraging recovered COVID-19 patients to donate plasma.
So far, the use of COVID-19 plasma has been limited primarily by the number of eligible donors. “The biggest issue right now, the main, main issue right now, is just building up the supplies,” Joyner said.
Potential donors are people with lab-confirmed cases of COVID-19, who have recovered from, and since tested negative for, the virus. Blood centers anticipate it eventually will be possible to collect tens of thousands of units of COVID-19 convalescent plasma, said Eduardo Nunes, the AABB’s vice president of quality, transfusion and standards.
But, for now, supplies remain scarce. “This will only work if people come out and donate so that there is an inventory available,” said Dr. Alyssa Ziman, director of transfusion medicine at UCLA Health, where the blood center is beginning plasma collection this week.
The promise of plasma, set against the scarcity of supply, has led to families seeking out their own sources. Last week, the family of Dr. Priya Khanna, a New Jersey nephrologist, turned to Twitter after she was sickened with COVID-19.
“Plasma donor needed urgently for my beautiful young sister who dedicated her life to helping others,” read a wrenching April 8 tweet shared widely by health care workers. Within a day, Khanna’s family reported they had found a donor.